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The K-12 Alliance has provided high-quality professional development in science and mathematics in California and on a national level since 1987.

The K-12 Alliance is a program within WestEd's Mathematics, Science, & Technology Program. A merger of the former California Science Implementation Network (CSIN), Science Partnerships for Articulation and Networking (SPAN), and Scope. Sequence, & Coordination (SS&C) programs, the K-12 Alliance has impacted more than 6000 schools, 175,000 teachers, and millions of K-12 students. It is cited as an exemplary professional development program in the Eisenhower National Clearinghouse document, Science Education Programs That Work; the National Staff Development Council document, Result-Based Professional Development Programs for Middle Grades; and in the book, Designing Professional Development for Teachers of Science and Mathematics.

K-12 Alliance staff and teacher leaders have been recognized for their contributions to science and math education as district Teachers of the Year, National Presidential Awardees in elementary and secondary teaching, and the California Science Teachers Association (CSTA)'s Distinguished Service Awards. They have also contributed to setting statewide science policy from 1990 to the present through their work with the 1998 California Science Content Standards, the 1990 and 2002 Science Framework, the California Science Expert Panel, California’s NGSS State Systemic Implementation Plan, and the 2016 California Science Framework. K-12 Alliance participants have also served on the instructional materials review panels since the early 1990s for both science and mathematics.

The K-12 Alliance Regional Directors received WestEd's Paul Hood Award for a team's Outstanding Contribution to the Field. Nominated by WestEd colleagues, this award was given in 2008 for the years of service the K-12 Alliance has provided to state and national science and math education programs.

Many state and national programs have sought out the K-12 Alliance as a partner. Some examples include: